承担项目
国家自然科学基金项目（81070550）：雷帕霉素靶蛋白(mTOR)信号转导在足细胞损伤中的作用及机制研究，负责人
国家自然科学基金项目（81570611）：FGF23促进急性肾损伤及其慢性化的作用和机制研究，负责人
代表性论文
1. Li J, Ren J, Liu X, Jiang L, He W, Yuan W, Yang J, Dai C. Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis. Kidney Int. 2015; 88(3):515-27.
2. Ji XB, Li XR, Hao-Ding, Sun Q, Zhou Y, Wen P, Dai CS, Yang JW. Inhibition of Uncoupling Protein 2 Attenuates Cardiac Hypertrophy Induced by Transverse Aortic Constriction in Mice. Cell Physiol Biochem. 2015; 36(5):1688-98.
3. Cao H, Ye H, Sun Z, Shen X, Song Z, Wu X, He W1, Dai C, Yang J. Circulatory mitochondrial DNA is a pro-inflammatory agent in maintenance hemodialysis patients. PLoS One. 2014; 9(12):e113179
4. Zhou Y, Xiong M, Niu J, Sun Q, Su W, Zen K, Dai C, Yang J. Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney. J Cell Sci. 2014; 127(Pt 20):4494-506.
5. Wen P, Song D, Ye H, Wu X, Jiang L, Tang B, Zhou Y, Fang L, Cao H, He W, Yang Y, Dai C, Yang J. Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients. PLoS One. 2014; 9(10):e103079.
6. Li J1, Xu Z, Jiang L, Mao J, Zeng Z, Fang L, He W, Yuan W, Yang J, Dai C. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. Kidney Int. 2014; 86(1):86-102.
7. Fang L, Li X, Luo Y, He W, Dai C, Yang J. Autophagy inhibition induces podocyte apoptosis by activating the pro-apoptotic pathway of endoplasmic reticulum stress. Exp Cell Res. 2014; 322(2):290-301.
8. Cao H, Wen P, Ye H, Sun Z, Shen X, Wu X, Dai C, Yang J. A study of the immunoloregulation of double filtration plasmapheresis in maintenance hemodialysis patients with chronic hepatitis C. PLoS One. 2013; 8(12):e82524.
9. Zhou Y, Xiong M, Fang L, Jiang L, Wen P, Dai C, Zhang CY, Yang J. miR-21-containing microvesicles from injured tubular epithelial cells promote tubular phenotype transition by targeting PTEN protein. Am J Pathol. 2013; 183(4):1183-96.
10. Jiang L, Qiu W, Zhou Y, Wen P, Fang L, Cao H, Zen K, He W, Zhang C, Dai C, Yang J. A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis. Kidney Int. 2013; 84(2):285-96.
11. Jiang L, Xu L, Mao J, Li J, Fang L, Zhou Y, Liu W, He W, Zhao AZ, Yang J, Dai C. Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis. J Am Soc Nephrol. 2013; 24(7):1114-26.
12. Fang L, Zhou Y, Cao H, Wen P, Jiang L, He W, Dai C, Yang J. Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLoS One. 2013; 8(4):e60546.
13. Zhou Y, Fang L, Jiang L, Wen P, Cao H, He W, Dai C, Yang J. Uric acid induces renal inflammation via activating tubular NF-κB signaling pathway. PLoS One. 2012; 7(6):e39738.
14. Wang D*, Dai C*, Li Y, Liu Y. Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria. Kidney Int. 2011; 80(11):1159-69. “*”: These authors contributed equally to this paper.
15. Dai C, Wen X, He W, Liu Y. Inhibition of proinflammatory RANTES expression by TGF-{beta}1 is mediated by glycogen synthase kinase-3{beta}-dependent {beta}-catenin signaling. J Biol Chem. 2011;286(9):7052-9.
16. Dai C, Holzman LB and Liu Y. Critical role of hepatocyte growth factor signaling in podocyte survival after injury in vivo and in vitro. Kidney Int. 2011;77(11):962-73.
17. Dai C, Stolz DB, Kiss L, Monga SP, Holzman LB and Liu Y.Wnt/-catenin signaling plays a role in the pathogenesis of podocyte dysfunction and albuminuria. J. Am. Soc. Nephrol. 2009;20(9):1997-2008.
18. Dai C, Stolz DB, Bastacky SI., St-Arnaud R, Holzman LB., Wu C, Dedhar S, and Liu Y. Essential role of integrin-linked kinase in podocyte biology: bridging the integrin and slit diaphragm signaling. J. Am. Soc. Nephrol. 2006;17:2164-2175.
