国家自然科学基金项目面上项目（81470040）高尿酸血症通过调控肾上皮钠通道(ENaC)介导盐敏感性高血压的机制研究，负责人

国家自然科学基金项目面上项目（31271263）Derlin-1在上皮细胞钠通道(ENaC)泛素化降解中的调控作用，负责人

国家自然科学基金项目面上项目（31071026）AS160对上皮细胞钠通道（ENaC）转运调控的分子机制研究，负责人，结题

 

代表论著

 

1. Li Y, Shen Y, Li M, Su D, Xu W, Liang X, Li R. Inhibitory effects of peroxisome proliferator-activated receptor γ agonists on collagen IV production in podocytes. Mol Cell Biochem. 2015; 405(1-2):233-41.

2. Li A, Shuai X, Jia Z, Li H, Liang X, Su D, Guo W. Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b. J Transl Med. 2015; 13:100

3. Ding Y, Xu Y, Shuai X, Shi X, Chen X, Huang W, Liu Y, Liang X, Zhang Z, Su D. Reg3α Overexpression Protects Pancreatic Beta-Cells From Cytokine-Induced Damage and Improves Islet Transplant Outcome. Mol Med. 2014

4. Li L, Shen Y, Ding Y, Liu Y, Su D, Liang X. Hrd1 participates in the regulation of collagen I synthesis in renal fibrosis. Mol Cell Biochem. 2014; 386(1-2):35-44.

5. Ren W, Guo J, Jiang F, Lu J, Ding Y, Li A, Liang X, Jia W. CCAAT/enhancer-binding protein α is a crucial regulator of human fat mass and obesity associated gene transcription and expression. Biomed Res Int. 2014; 2014:406909.

6. Jia L, Xing J, Ding Y, Shen Y, Shi X, Ren W, Wan M, Guo J, Zheng S, Liu Y, Liang X, Su D. Hyperuricemia causes pancreatic β-cell death and dysfunction through NF-κB signaling pathway. PLoS One. 2013; 8(10):e78284

7. Wu RP, Liang XB, Guo H, Zhou XS, Zhao L, Wang C, Li RS. Protective effect of low potassium dextran solution on acute kidney injury following acute lung injury induced by oleic acid in piglets. Chin Med J (Engl). 2012; 125(17):3093-7. 

8. Liang X, Butterworth MB, Peters KW, Walker WH, Frizzell RA. An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel. J Biol Chem. 2008;283:27418-27425

9. Zhang Y, Zhang H, Hou P, Liang X, Li Z, Wang H. The novel gene AngRem104 downregulatesglucocorticoid receptor expression and activates NF-kappaB in human mesangial cells. Biochem Biophys Res Commun. 2008;369:1057-1060

10.Liang X, Peters KW, Butterworth MB, Frizzell RA. 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. J Biol Chem. 2006;281:16323-16332

11. Liang XB, Ma LJ, Naito T, Wang Y, Madaio M, Zent R, Pozzi A, Fogo AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol. 2006;17:1886-1895

12. Liang X, Kanjanabuch T, Mao SL, Hao CM, Tang YW, Declerck PJ, Hasty AH, Wasserman DH, Fogo AB, Ma LJ. Plasminogen activator inhibitor-1 modulates adipocyte differentiation. Am J Physiol Endocrinol Metab. 2006;290:E103-E113

13. Ma LJ, Nakamura S, Aldigier JC, Rossini M, Yang H, Liang X, Nakamura I, Marcantoni C, Fogo AB. Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1. J Am Soc Nephrol. 2005;16:966-976

14. Xu BJ, Shyr Y, Liang X, Ma LJ, Donnert EM, Roberts JD, Zhang X, Kon V, Brown NJ, Caprioli RM, Fogo AB. Proteomic patterns and prediction of glomerulosclerosis and its mechanisms. J Am Soc Nephrol. 2005;16:2967-2975

15. Liang X, Zhang H, Zhou A, Wang H. AngRem104, an angiotensin II-induced novel upregulated gene in human mesangial cells, is potentially involved in the regulation of fibronectin expression. J Am Soc Nephrol. 2003;14:1443-1451

16. Liang XB, Zhang H, Zhou AY, Wang HY. Screening for functional genes related to a novel gene, AngRem104, in human mesangial cells by cDNA microarray. Biotechnol Lett. 2003;25:139-142

17. Liang X, Zhang H, Zhou A, Hou P, Wang H. Screening and identification of the up-regulated genes in human mesangial cells exposed to angiotensin II. Hypertens Res. 2003;26:225-235