研究领域

1. 建立转基因或基因敲除的克隆猪作为异种移植的供体。

2. 建立新型的转基因大动物作为人类疾病的大动物模型以及培育农业新品种。

3. omega-3脂肪酸在抑制多种人类代谢疾病和癌症上的作用。

代表论文 

1.  Dai Y, Roman M, Naviaux RK, Verma IM (1992) Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo. Proceedings of the National Academy of Sciences 89: 10892-10895

2.    Dai Y, Schwarz EM, Gu D, Zhang WW, Sarvetnick N, Verma IM (1995) Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.Proceedings of the National Academy of Sciences 92: 1401-1405

3.     Dai Y, Vaught TD, Boone J, Chen S-H, Phelps CJ, Ball S, Monahan JA, Jobst PM, McCreath KJ, Lamborn AE, Cowell-Lucero JL, Wells KD, Colman A, Polejaeva IA, Ayares DL (2002) Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs. Nat Biotech 20: 251-255

4.    Lai L, Kang JX, Li R, Wang J, Witt WT, Yong HY, Hao Y, Wax DM, Murphy CN, Rieke A, Samuel M, Linville ML, Korte SW, Evans RW, Starzl TE, Prather RS, Dai Y (2006) Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nat Biotech 24: 435-436

5.     Lu Y, Nie D, Witt WT, Chen Q, Shen M, Xie H, Lai L, Dai Y, Zhang J (2008) Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3β phosphorylation. Molecular Cancer Therapeutics 7: 3203-3211

6.    Phelps CJ, Koike C, Vaught TD, Boone J, Wells KD, Chen S-H, Ball S, Specht SM, Polejaeva IA, Monahan JA, Jobst PM, Sharma SB, Lamborn AE, Garst AS, Moore M, Demetris AJ, Rudert WA, Bottino R, Bertera S, Trucco M, Starzl TE, Dai Y, Ayares DL (2003) Production of α1,3-Galactosyltransferase-Deficient Pigs. Science 299: 411-414

7.    Polejaeva IA, Chen S-H, Vaught TD, Page RL, Mullins J, Ball S, Dai Y, Boone J, Walker S, Ayares DL, Colman A, Campbell KHS (2000) Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 407: 86-90

8     Wen ZH, Su YC, Lai PL, Zhang Y, Xu YF, Zhao A, Yao GY, Jia CH, Lin J, Xu S, Wang L, Wang XK, Liu AL, Jiang Y, Dai YF, Bai XC (2013) Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis. Oncogene 32: 160-1709

9.    Hara H*, Witt W, Crossley T, Long C, Isse K, Fan L, Phelps CJ. Ayares D. Copper DK, Dai Y*, Starzl TE (2013) Human dominant-negative class II transactivator transgenic pigs-effect on the human anti-pig t cell immune response and immune status. Immunology 140 : 39-46

10.  Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin Jun, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y, Bai X. (2014) mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Oncogene 33: 4548–4557  

11. Li Jie,* Li FH,* Wei D, Jia W, Kang JX, Racic MS, Dai YF, Zhao Z. (2014) Endogenous ω-3 Polyunsaturated Fatty Acid Production Confers Resistance to Obesity, Dyslipidemia, and Diabetes in Mice. Molecular Endocrinology 28: 1316–1328

12. Chen F, Wang Y, Yuan Y, Zhang W, Ren Z, Jin Y, Liu X, Xiong Q, Chen Q, Zhang M, Li X, Zhao L, Li Z, Wu Z, Zhang Y, Hu F, Huang J, Li R, Dai Y. (2015) Generation of B Cell-Deficient Pigs by Highly Efficient CRISPR/Cas9-Mediated Gene Targeting. J Genet Genomics 42(8): 437-44.