刘永坚，教授，博士生导师

研究方向：分子细胞生物学及在神经退行性病的发病机制中的作用

地址：南京市汉中路140号生理学系

手机：13905164759

E-mail:yjliu78@njmu.edu.cn

主要研究领域包括单胺类神经递质传递分子药理机制及巴金森氏病的发病机理中的运用，后又将细胞膜运输的概念融入神经递质传递和神经特异性亚细胞器如突触囊泡等的形成和功能研究中，并在研究细胞逆膜运输（Retrograde Endosome-to-TGN Trafficking）的分子机制发面报道了一系列原创性 成果 ，成果发表在著名杂志“细胞”，“科学”，“PNAS”等

代表性的论文：
1.Liu, Y., Peter, D., Roghani, A., Schuldiner, S., Prive, G.G., Eisenberg, D., Brecha, N. and Edwards, R.H. (1992) A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter. Cell  70:539-551.
  2.Chen CX, Huang SY, Zhang L and Liu YJ. (2005) Synaptophysin enhances the neuroprotection of VMAT2 in MPP+-induced toxicity in MN9D cells. Neurobiol Dis. 19(3): 419-26.
  3.Colgan L, Liu H, Huang SY, and Liu YJ. (2007) Dileucine motif is sufficient for internalization and synaptic vesicle targeting of vesicular acetylcholine transporter. Traffic 8(5): 512-22.
  4.Bai, X., Ma, D., Shen, X.Y., Qiming Wang, Q., Liu, YJ. and Jiang, Y. (2007) Rheb activates mTOR by antagonizing its inherent inhibitor, FKBP38. Science 318(5852):977-80. 
  5.Koharudin, LMI., Furey, W., Liu, H., Liu, YJ. and Gronenborn, AM. (2009) The phox
  domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). J. Biol. Chem. 284, 23697-70. Zhou H., Huang C., Tong, J., Hong, WC., Liu YJ*. and Xia, XG. (2011) Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake. Int. J. Biol. Sci. 7(6):753-61. *Corresponding author 
  6.Zou, H., Lai, Y., Zhao, Y., Yan, G., Ma, D., Cardenes, N., Shiva, S., Liu, Y., Bai, X. and Jiang, Y. (2013) Regulation of mammalian target of rapamycin complex 1 by Bcl-2 and Bcl-XL proteins. J Biol Chem 288:28824-30
  7Gallo, L., Liao, Y., Ruiz, WG., Li, M., Liu, YJ., Jiang, Y., Fukuda, M., Apodaca, G. and Yin, XM. (2014) TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Mol. Biol. Cell. 25(23):3779-97.
  8.Plowey, ED., Johnson, JW., Eisenberg, DA., Valentino, NM., Liu, YJ. and Chu, CT. (2014) Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration. BBA 1842:1596-603.
  9.Zhao, X., Zhong, M., Yuan, W., Yan, G., Tong, M., Guo, S., Zhu, Y., Jiang, Y., Liu, YJ., and Yu Jiang (2015) Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia. EMBO J. submitted.